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3Inhibition of the mid-cycle surge of FSH and LH as well as alterations in the pulsatility of LHDanazol can also reduce the mean plasma levels of these gonadotrophins after the menopause.
The possible causal relationship between danazol and many of the following events reportedly associated with its use remains to be defined.
Ethyl AlcoholSubjective intolerance in the form of nausea and shortness of breath has been reported.
Flushingsweatingvaginal dryness and irritation and reduction in breast sizemay reflect lowering of estrogenNervousness and emotional lability have been reportedIn the male a modest reduction in spermatogenesis may be evident during treatmentAbnormalities in semen volumeviscositysperm countand motility may occur in patients receiving long-term therapy.
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figure 78 2012-2017 global danazol consumption volume market by application.